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Evidence is increasing that every addiction without exception is related to problems with the brain's reward center, specially the mesolimbic system. This the main problem regulates reward responses in establishing food and sex, plus in nurturing infants and children. One of the most important neurotransmitters linked to reward responses, both whenever they malfunction and once they function properly, is dopamine. What makes opiates unique is that it, among other neurotransmitters modulates "the volume of dopamine released in responding to a stimulus"(Bostwick & Bucci, 2008). Using two separate drugs to lose weight can be very effective you can find combinations in front of the FDA now awaiting approval. When dealing with weight reduction and the people that go through it one should err assisting caution and allow the FDA do its job and demand some study be done so the public is aware of the side effects and perils associated with the medications before we bring them. Keep in mind that drug companies are in business to generate income and that they would say almost anything to keep people on his or her medications.Researchers found that participants taking this drug for any year, dropped excess weight within a month and have kept the body weight off through the entire 56 weeks in the study. Contrave is really a combination from the drugs naltrexone and bupropion, which appears to reflect a whole new trend of weight-loss drugs that are made up of multiple active ingredient, which might make them more efficient and safer. Combo-pilling could be the newest fad or even better the newest ahead under scrutiny and thus it is just more publicly known in recent months, comb-pilling for weight reduction has been around since the eighties. The biggest reason that by using a combination of pills is becoming popular may be the fact that at the time of right now there aren't any long term prescription weightloss pills that have been approved by the FDA other than orlistat. The truly disturbing part is that doctors are prescribing these combinations of medications and some of the combinations are actually rejected or have yet to be approved by the FDA.Seizures certainly are a side effect with Contrave and must not be taken in individuals with seizure disorders. The drug could also raise hypertension and heart rate, and really should not be used in people who have a history of cardiac event or stroke in the previous six months. Blood pressure and pulse should also be measured before starting the drug and throughout therapy with the drug.The FDA also warned that Contrave can raise blood pressure and heartbeat and must 't be used in patients with uncontrolled high blood pressure level, in addition to by you are not heart-related and cerebrovascular (circulation dysfunction impacting mental performance) disease. Patients having a history of heart attack or stroke in the earlier six months, life-threatening arrhythmias, or congestive heart failure were excluded through the clinical trials. Those taking Contrave should have their heart-rate and pulse monitored regularly. In addition, since the compound includes bupropion, Contrave comes with a boxed warning to alert medical researchers and patients on the increased likelihood of suicidal thoughts and behaviors associated with antidepressant drugs. The warning also notes that serious neuropsychiatric events happen to be reported in patients taking bupropion for quitting smoking.BioCorRx, Inc.'s naltrexone implant isn't any bigger than a thumb and is inserted within the patient's skin via a 30-minute, minimally invasive outpatient procedure made by a healthcare professional. The implant is administered within BioCorRx, Inc.'s Start Fresh Program which can be distributed in numerous states by independent rehabilitation facilities.